Casodex is used for:

Treating prostate cancer. Casodex is intended for use with other medicines. Casodex may be used to treat conditions as determined by your doctor, which may not be listed in the professional package insert.

Casodex is a nonsteroidal antiandrogen. It works by blocking the action of testosterone.

Do NOT use Casodex if:

• you are allergic to any ingredient in Casodex
• you are pregnant, planning to become pregnant, or are breast-feeding

Contact your doctor or health care provider right away if any of these apply to you.

Before using Casodex:

Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

• if you are a woman
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have liver disease

Some MEDICINES MAY INTERACT with Bicalutamide. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Oral anticoagulants (eg, warfarin) because side effects, including risk of bleeding, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Bicalutamide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Casodex:

Use Casodex as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Bicalutamide may be taken with or without food.
• Take Bicalutamide with your other prostate cancer medicine at the same time each day.
• If you miss a dose of Casodex, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Casodex.

Important safety information:

• Casodex may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Bicalutamide. Using Casodex alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
• Casodex may cause constipation or diarrhea. If you experience either constipation or diarrhea, ask your doctor or pharmacist to recommend a treatment for you.
• LAB TESTS, including liver function tests and prostate-specific antigen (PSA), may be required to monitor your progress. Be sure to keep all doctor and lab appointments.
• Use Casodex with caution in the ELDERLY because they may be more sensitive to its effects.
• Casodex is not recommended for use in CHILDREN; safety and effectiveness have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Do not use Casodex if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. It is unknown if Casodex is excreted in breast milk. Do not breast-feed while taking Bicalutamide.

Possible side effects of Casodex:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensations; anxiety; arthritis; back pain; bone pain; breast growth or pain; bronchitis; constipation; decreased sexual ability; depression; diarrhea; dizziness; frequent urination; gas; hot flashes; impotence; increased cough; indigestion; infection; loss of bladder control; muscle weakness; nausea; pain; pelvic pain; rash; runny nose; sleeplessness; sore throat; sweating; urinary retention; weakness; weight change.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dark urine; difficulty breathing; flu-like symptoms; loss of appetite; muscle aches; nausea; pneumonia; stomach pain; tenderness of the right upper quadrant; tiredness; vomiting; yellowing of the skin or eyes.

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